Mpox 2025 Global Update: Epidemiological Trends, Clinical Considerations, and Public Health Response

Press Release For Immediate Release Muscat, July 14, 2025 Global Mpox Update – Rising Burden in Africa and Renewed Calls for Vaccination Mpox, formerly known as monkeypox, continues to pose a global health challenge, with distinct transmission patterns seen in clade I (Central Africa) and clade IIb (worldwide outbreak strain). Key Findings from WHO & CDC Reports - More than 100,000 mpox cases have been confirmed globally since the 2022–23 epidemic. - Clade I activity is rising in Africa, particularly the Democratic Republic of Congo (DRC), with over 24,000 cumulative cases reported since 2024. - Sierra Leone alone accounted for 41% of new global cases last week. - Vaccine coverage in Africa remains limited despite 700,000 doses distributed, largely due to reduced donor funding. - In the U.S. and other non-endemic countries, most clade IIb cases occur in unvaccinated or partially vaccinated individuals. Travel & Vaccination Advisory The CDC recommends travelers to countries with clade I outbreaks—including DRC, Uganda, Kenya, Central African Republic, and Cameroon—receive the two-dose JYNNEOS vaccine at least two weeks prior to travel. Infection Prevention in Healthcare Healthcare facilities must apply strict IPC measures for suspected mpox cases: - Immediate isolation in single rooms with dedicated bathrooms. - Contact and droplet precautions. - Surface disinfection with EPA-registered agents. - Safe linen and waste handling to prevent re-aerosolization of virus particles. Expert Comment “Mpox remains a preventable but serious global health challenge. Sustained international support is vital to protect Africa and prevent resurgence globally. Healthcare workers must remain vigilant, and vaccination of high-risk populations is essential,” said Dr. Abdullah Alqayoudhi, MD, FRCPI, CIC – Consultant in Infection Prevention & Control. Conclusion A coordinated, science-based response—centered on equitable vaccine access, enhanced surveillance, and clinical vigilance—remains key to controlling mpox worldwide. For further details: WHO Mpox Situation Reports: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON385 CDC Mpox Updates: https://www.cdc.gov/mpox/situation-summary/